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  • Friday, Nov 17th
    11:25 AM – 11:35 AM PT
    DDDR-24 - Single-cell functional tissue profiling identifies promising candidates for drug repurposing against glioblastoma
    Location: Room 109-110
    Oral Abstract Presenter: Tobias Weiss – Department of Neurology and Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland
    Author: Sohyon Lee – Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Author: Marcel Buehler – Department of Neurology and Clinical Neuroscience Center, University Hospital and University of Zurich, Switzerland
    Author: Julien Mena – Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Author: Zuzanna Lottenbach – Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Author: Rebekka Wegmann – Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Author: Michael Bihl – Institute of Pathology, University Hospital Zurich, Zurich, Switzerland
    Author: Miaomiao Sun – Department of Neurology and Clinical Neuroscience Center, University Hospital and University of Zurich, Switzerland
    Author: Sandra Goetze – Department of Health Sciences and Technology, ETH Zürich, Switzerland
    Author: Audrey van Drogen – Department of Health Sciences and Technology, ETH Zürich, Switzerland
    Author: Flavio Vasella – Department of Neurosurgery and Clinical Neuroscience Center, University Hospital and University of Zurich, Switzerland
    Author: Bernd Wollscheid – Department of Health Sciences and Technology, ETH Zürich, Switzerland
    Author: Berend Snijder – Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Author: Michael Weller – Department of Neurology and Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland
    Drug discovery, drug resistance
  • Friday, Nov 17th
    4:15 PM – 4:25 PM PT
    DDDR-17 - Clinical response to the PDGFRA/KIT inhibitor avapritinib in pediatric and young adult high-grade glioma patients
    Location: Room 121-122
    Author: Lisa Mayr – Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna
    Author: Maria Trissal – Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center
    Author: Kallen Schwark – University of Michigan
    Oral Abstract Presenter: Sina Neyazi – Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center
    Author: Alexander Beck – Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA
    Author: Jenna Labelle – Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center
    Author: Joana Graca Marques – Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center
    Author: Liesa Weiler-Wichtl – Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna
    Author: Sibylle Madlener – Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna
    Author: Seongbae Kong – Department of Pediatrics, University of Michigan Medical School, Ann Arbor
    Author: Madeline Miclea – University of Michigan
    Author: Jeffrey Supko – Department of Medicine, Massachusetts General Hospital
    Author: Armin Sebastian Guntner – Institute of Analytical Chemistry, Johannes Kepler University
    Author: Hana Palova – Central European Institute of Technology, Masaryk University
    Author: Jakub Neradil – Laboratory of Tumor Biology, Department of Experimental Biology, Faculty of Science, Masaryk University
    Author: Natalia Stepien – Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center
    Author: Daniela Loetsch-Gojo – Department of Neurosurgery, Medical University of Vienna, Vienna, Austria
    Author: Christian Dorfer – Department of Neurosurgery, Medical University of Vienna
    Author: Karen Dieckmann – Department of Radiotherapy, Medical University of Vienna
    Author: Andreas Peyrl – Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University Vienna
    Author: Amedeo A A. Azizi – Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna
    Author: Alicia-Christina Baumgartner – Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna
    Author: Ondrej Slaby – Central European Institute of Technology, Masaryk University, Brno
    Author: Petra Pokorna – Central European Institute of Technology, Masaryk University
    Author: Frank Dubois – Dana-Farber Cancer Institute
    Author: Noah Greenwald – Stanford University
    Author: Pratiti Bandopadhayay – Dana-Farber Cancer Institute
    Author: Rameen Beroukhim – Center for Neuro-Oncology, Dana-Farber Cancer Institute
    Author: Keith L. Ligon – Brigham and Women's Hospital
    Author: Christof Kramm – Division of Pediatric Hematology and Oncology, University Medical Center Göttingen
    Author: Annika Bronsema – Clinic of Paediatric Haematology and Oncology, University Medical Centre Hamburg-Eppendorf
    Author: Simon Bailey – Great North Childrens Hospital and Newcastle University
    Author: Ana Guerreiro Stuecklin – Kispi
    Author: Sabine Mueller – University of California, San Francisco
    Author: Mary Skrypek – Department of Pediatric Hematology-Oncology, Children’s Minnesota
    Author: Nina Martinez – Department of Neurology & Neurological Surgery, Jefferson University
    Author: Daniel C C. Bowers – Department of Pediatrics, University of Texas Southwestern Medical Center
    Author: David TW Jones – German Cancer Research Center (DKFZ)
    Author: Chris Jones – Division of Molecular Pathology, Institute of Cancer Research
    Author: Natalie Jaeger – Hopp Children's Cancer Center Heidelberg (KiTZ) & Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ)
    Author: Jaroslav Sterba – Department of Pediatric Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University
    Author: Leonhard Müllauer – Department of Pathology, Medical University of Vienna
    Author: Christine Haberler – Medical University of Vienna
    Author: Chandan Kumar-Sinha – University of Michigan
    Author: Arul Chinnaiyan – University of Michigan
    Author: Rajen Mody – University of Michigan
    Author: Julia Furtner-Srajer – Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna
    Author: Carl J. Koschmann – University of Michigan
    Author: Johannes Gojo – Pediatrics and Adolescent Medicine, Comprehensive Cancer Center and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090, Austria
    Author: Mariella G. Filbin – Dana-Farber/Boston Children’s Cancer and Blood Disorder Center
    Drug discovery, drug resistance
  • Friday, Nov 17th
    5:00 PM – 5:05 PM PT
    DDDR-28 - DNA damage sensing kinases ATR and ATM-dependent phosphorylation of  RRM2 promotes protein stabilization and chemo-adaptation
    Location: Room 118-120
    Oral Abstract Presenter: Graysen N. McManus – Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University
    Author: Ella Perrault – Harvard University
    Author: Cheol Park – Northwestern
    Author: Divya Ventrapragada – Northwestern University
    Author: Shreya Budhiraja – Northwestern Univeristy
    Author: Killian Buechler – Northwestern University
    Author: Amelia Stepniak – Northwestern University
    Author: Snehasis Mishra – Northwestern University
    Author: Jason Miska – Northwestern University
    Author: Atique U. Ahmed – Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-01 - p38-MAPK inhibitor reversed cisplatin resistance in non-small cell lung cancer brain metastases by regulating P-gp and BCRP of blood-tumor barrier
    Location: Exhibit Hall A/B
    Poster Presenter: Lun Liang – Sun Yat-sen University Cancer Center
    Author: Min Yu – Chinese Academy of Science
    Author: Shilun Yang – Chinese Academy of Science
    Author: Hao Duan – Sun Yat-sen University Cancer Center
    Author: Zhenqiang He – Sun Yat-sen University Cancer Center
    Author: Zhenning Wang – Sun Yat-sen University Cancer Center
    Author: Junlei Chang – Chinese Academy of Science
    Author: Yonggao Mou – Sun Yat-sen Cancer Center
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-03 - Drug Repurposing via ultra-High Throughput 3D Spheroids Screening for Human Schwannoma
    Location: Exhibit Hall A/B
    Poster Presenter: Kecheng Lei – Emory University
    Author: Muhibullah Tora – Emory University
    Author: Yuliya Lakhina – Emory University
    Author: Michelle Zhang – Emory University
    Author: Min Qui – Emory University
    Author: Haian Fu – Emory University
    Author: Yuhong Du – Emory University
    Author: Nicholas Boulis – Emory University
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-04 - Transient suppression of XPO1 activity is sufficient for Selinexor-induced cytotoxicity in glioblastoma cells lines.
    Location: Exhibit Hall A/B
    Author: Yongjian Tang – University of California San Francisco
    Author: Lisa Sprinzen – University of California San Francisco
    Author: Yukinori Terada – University of California San Francisco
    Poster Presenter: Russell O. Pieper – University of California, San Francisco
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-06 - The smoking cessation agent lobeline delays hypoxic stress recovery resulting in glioblastoma cell death
    Location: Exhibit Hall A/B
    Poster Presenter: Kathleen M. Attwood – Dalhousie University Department of Surgery
    Author: Lauren Westhaver – Dalhousie University
    Author: Aaron Robichaud – Dalhousie University, Division of Neurosurgery
    Author: Jae Ho Han – Dalhousie University Division of Neurosurgery
    Author: Gabriel Wajnberg – Atlantic Cancer Research Institute
    Author: Jeremy Roy – Atlantic Cancer Research Institute
    Author: Adrienne Weeks – Dalhousie University Division of Neurosurgery
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-10 - Sirtuin 2 inhibition selectively induces senescence in ATRX-deficient malignant gliomas by modulating chromatin landscapes genome-wide
    Location: Exhibit Hall A/B
    Author: Prit Benny Malgulwar – University of Texas MD Anderson Cancer Center
    Author: Carla Danussi – Sanofi
    Author: Sharvari Dharmaiah – University of Texas MD Anderson Cancer Center
    Author: William E Johnson – University of Texas MD Anderson Cancer Center
    Author: Arvind U. Rao – University of Michigan
    Poster Presenter: Jason T. Huse – University of Texas MD Anderson Cancer Center
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-11 - Identifying new vulnerabilities to target pediatric low-grade glioma
    Location: Exhibit Hall A/B
    Poster Presenter: Anna Borgenvik – Dana-Farber Cancer Institute
    Author: Sean Misek – Broad Institute of MIT and Harvard
    Author: Jens Maile – Dana-Farber Cancer Institute
    Author: Dana Novikov – Dana-Farber Cancer Institute
    Author: Sher Bahadur – Dana-Farber Cancer Institute
    Author: April Apfelbaum – Dana-Farber Cancer Institute
    Author: Eric Morin – Dana-Farber Cancer Institute
    Author: Alexandra Condurat – Dana-Farber Cancer Institute
    Author: Elizabeth Gonzales – Broad Institute of MIT and Harvard
    Author: Kevin Zhou – Dana-Farber Cancer Institute
    Author: Amy Goodale – Broad Institute of MIT and Harvard
    Author: Tanaz Abid – Broad Institute of MIT and Harvard
    Author: Zohra Kalani – Broad Institute of MIT and Harvard
    Author: Federica Piccioni – Broad Institute of MIT and Harvard
    Author: Keith L. Ligon – Brigham and Women's Hospital
    Author: Rameen Beroukhim – Center for Neuro-Oncology, Dana-Farber Cancer Institute
    Author: Nicole Persky – Broad Institute of MIT and Harvard
    Author: David TW Jones – German Cancer Research Center (DKFZ)
    Author: David E. Root – Broad Institute of MIT and Harvard
    Author: Pratiti Bandopadhayay – Dana-Farber Cancer Institute
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-12 - Establishing a safe and efficacious anti-glioblastoma therapy
    Location: Exhibit Hall A/B
    Author: Carmen L. del Genio – Dartmouth Hitchcock Medical Center
    Author: Sidney M. Nguyen – Dartmouth Hitchcock Medical Center
    Author: Arti B. Gaur – Dartmouth Hitchcock Medical Center
    Author: Elizabeth M. Pizzi – Bates College
    Author: Bamlak A. Messay – Dartmouth College
    Author: Dominique B. Fontaine – Dartmouth Hitchcock Medical Center
    Author: Yujia Shentu – Dartmouth College
    Author: Heather A. Wishart – Dartmouth College
    Author: James C. Ford – Dartmouth College
    Author: Glenn C. Micalizio – Dartmouth College
    Poster Presenter: Arti B. Gaur – Dartmouth Hitchcock Medical Center
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-13 - ST-401, a Brain Penetrating Microtubule Targeting Agent that kills Glioblastoma in Interphase and by Disrupting Mitochondria Function.
    Location: Exhibit Hall A/B
    Poster Presenter: Kainat Khan – Department of Pharmacology, University of Washington
    Author: Dennis Sarroza – Department of Pharmacology, University of Washington
    Author: Juan J. Vicente, Washington – Department of Physiology and Biophysics, University of Washington
    Author: Linda G. Wordeman, Washington – Department of Physiology and Biophysics, University of Washington
    Author: Yasemin S. Sancak – Department of Pharmacology, University of Washington
    Author: Nephi Stella – Departments of Pharmacology, Psychiatry and Behavioral Sciences, University of Washington
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-14 - Development of a novel CYP17A1-targeted inhibitor for glioblastoma
    Location: Exhibit Hall A/B
    Poster Presenter: Hsien-Chung Chen – Shuang Ho Hospital
    Author: Tsung-I Hsu – Ph.D. Program in Medical Neuroscience, Taipei Medical University
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-15 - Resistance to Targeted Anti-Mitotics in Glioblastoma is Driven by STAT3 Activation and Therapy Induced Senescence
    Location: Exhibit Hall A/B
    Poster Presenter: Rajappa S. Kenchappa – Mayo Clinic
    Author: Natanael Zarco – Mayo Clinic
    Author: Athanassios Dovas – Columbia University Medical Center
    Author: Michael G. Argenziano – Columbia University Medical Center
    Author: Ashley Haddock – Mayo Clinic
    Author: Peter D. Canoll – Columbia University Irving Medical Center
    Author: Steven S. Rosenfeld – Mayo Clinic Florida
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-18 - Single-cell functional genomic analysis of pharmacologic responses in NF1 mutant glioblastoma reveals distinct mechanisms of action for MEK and SHP2 inhibition
    Location: Exhibit Hall A/B
    Poster Presenter: Sixuan Pan – UCSF
    Author: John Liu – UCSF
    Author: Kanish Mirchia – UCSF
    Author: Emily Payne – UCSF
    Author: Joanna Pak – UCSF
    Author: Kyounghee Seo – UCSF
    Author: Tomoko Ozawa – UCSF
    Author: David R. Raleigh – University of California, San Francisco
    Author: Mitchel S. Berger – University of California, San Francisco
    Author: Adam R. Abate – UCSF
    Author: Harish N. Vasudevan – UCSF
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-19 - First-in-class cancer therapeutics targeting the DNA Damage Response
    Location: Exhibit Hall A/B
    Poster Presenter: Adam Robertson – Hemispherian
    Author: Terezia Prikrylova – Hemispherian
    Author: Hope Lancero – Stanford University
    Author: Christy Wilson – Stanford University
    Author: Claudia K. Petritsch – Stanford University
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-20 - FOSL1 induces TMZ-chemoresistance in glioblastoma via regulation of IL-6-STAT3Tyr705 pathway-mediated stemness
    Location: Exhibit Hall A/B
    Poster Presenter: Jeongmin Sim – Department of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine
    Author: JeongMan Park – Department of Biomedical Science, College of Life Science, CHA University
    Author: Yu Jin Kim – Department of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine
    Author: Dongkil Kim – Department of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine
    Author: Kyunggi Cho – Department of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine
    Author: Ju Hyung Moon – Severance Hospital, Yonsei University College of Medicine
    Author: Kyoung Su Sung – Department of Neurosurgery, Dong-A University Hospital, Dong-A University College of Medicine
    Author: Jaejoon Lim – Department of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-21 - A temozolomide-induced long noncoding RNA, linc02454, regulates chemosensitivity in glioblastoma via modulation of CXCR4
    Location: Exhibit Hall A/B
    Author: Edith Yuan – University of California, Los Angeles
    Author: Kathleen Tsung – Keck School of Medicine of USC
    Poster Presenter: Jane S. Han – Keck School of Medicine of USC
    Author: Wange Lu – Nankai University
    Author: Frank J. Attenello – Keck School of Medicine of USC
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-22 - Predicting and targeting clonally expanding, TMZ-resistant tumor cells in glioblastoma
    Location: Exhibit Hall A/B
    Poster Presenter: Vivien Ullrich – DKFZ-Division Translational Neurooncology, West German Cancer Center, University Hospital Essen, Essen, Germany and German Cancer Consortium (DKTK)
    Author: Sarah Ertmer – DKFZ-Division Translational Neurooncology, West German Cancer Center, University Hospital Essen, Essen, Germany and German Cancer Consortium (DKTK)
    Author: Pia Berger – DKFZ-Division Translational Neurooncology, West German Cancer Center, University Hospital Essen, Essen, Germany and German Cancer Consortium (DKTK)
    Author: Sarah Langer – DKFZ-Division Translational Neurooncology, West German Cancer Center, University Hospital Essen, Essen, Germany and German Cancer Consortium (DKTK)
    Author: Anna Baginska – Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany and German Cancer Consortium (DKTK)
    Author: Hanah Gull – Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany and Center for Translational Neuroscience and Behavioral Science (C-TNBS)
    Author: Madeleine Dorsch – Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany and German Cancer Consortium (DKTK)
    Author: Igor Cima – DKFZ-Division Translational Neurooncology, West German Cancer Center, University Hospital Essen, Essen, Germany and German Cancer Consortium (DKTK)
    Author: Celia Dobersalske – DKFZ-Division Translational Neurooncology, West German Cancer Center, University Hospital Essen, Essen, Germany and German Cancer Consortium (DKTK)
    Author: Sied Kebir – Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany
    Author: Martin Glas – Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany
    Author: Laurèl Rauschenbach – Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany and Center for Translational Neuroscience and Behavioral Science (C-TNBS)
    Author: Ulrich Sure – Department of Neurosurgery and Spine Surgery, University Medicine Essen, University Duisburg-Essen, Essen, Germany
    Author: Alexander Roesch – Department of Dermatology, West German Cancer Center, University Hospital Essen, Essen, Germany and German Cancer Consortium (DKTK)
    Author: Barbara M. Gruener – Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany and German Cancer Consortium (DKTK)
    Author: Björn Scheffler – German Cancer Research Center (DKFZ), Heidelberg, Germany
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-23 - Combination therapy with paclitaxel, carboplatin, and low-intensity ultrasound for recurrent glioblastoma: rationale for ongoing phase II clinical trial
    Location: Exhibit Hall A/B
    Poster Presenter: Karl Habashy – Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University
    Author: Crismita Dmello – Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University
    Author: Li Chen – Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University
    Author: Victor A. Arrieta – Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University
    Author: Kwang-Soo Kim – Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University
    Author: Andrew Gould – Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University
    Author: Guillaume Bouchoux – Carthera
    Author: Michael Canney – Carthera
    Author: Roger Stupp – Lou and Jean Malnati Brain Tumor Institute, Robert H. Lurie Comprehensive Cancer Center of Northwestern University
    Author: Adam M. Sonabend – Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-26 - Inhibition of RAD52 activity enhances the radiosensitivity in DIPG
    Location: Exhibit Hall A/B
    Poster Presenter: Eita Uchida – Department of Pediatrics, University of Alabama at Birmingham
    Author: Yukitomo Ishi – Department of Pediatrics, Northwestern University Feinberg School of Medicine
    Author: Jun Watanabe – University of Alabama-Birmingham
    Author: Lu Wang – Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University
    Author: Hiam Abdala-Valencia – Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
    Author: Samantha L. Gadd – Division of Hematology, Oncology, Neuro-Oncology & Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago
    Author: Rintaro Hashizume – Division of Pediatric Hematology and Oncology, Children’s of Alabama
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-27 - Class I HDAC inhibitor against TM-mediated network connectivity in glioblastoma 
    Location: Exhibit Hall A/B
    Poster Presenter: Sophie Heuer – Neurology Clinic University Hospital Heidelberg & German Cancer Research Center
    Author: Daniel D. Domínguez Azorín – German Cancer Research Center
    Author: Dirk C. Hoffmann – German Cancer Research Center
    Author: Sandra Horschitz – Hector Institute for Translational Brain Research (HITBR), Central Institute of Mental Health (CIMH), J5, 68159 Mannheim, Germany
    Author: Ammar Jabali – Hector Institute for Translational Brain Research (HITBR), Central Institute of Mental Health (CIMH), J5, 68159 Mannheim, Germany
    Author: Erik Jung – Heidelberg University Hospital and National Center for Tumor Diseases (NCT)
    Author: Philipp Koch – Hector Institute for Translational Brain Research (HITBR), Central Institute of Mental Health (CIMH), J5, 68159 Mannheim, Germany
    Author: Wolfgang Wick – Universitatsklinikum Heidelberg
    Author: Frank Winkler – German Cancer Research Center
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-29 - Targeting FGFR fusions: a case of catequentinib (AL3818) and temozolomide combination therapy for recurrent MGMT methylated TACC-FGFR fusion positive glioblastoma
    Location: Exhibit Hall A/B
    Author: Andreas Seas – Duke University School of Medicine, The Duke Medical Scientist Training Program (MSTP)
    Author: Mallika P. Patel – Duke University Hospital, Department of Pharmacy
    Author: Martin Kowalsky – Duke University Hospital, Department of Pharmacy Investigational Drug Services
    Author: Daniel S. Rudd – Duke University Hospital
    Author: Susanne D. Jacobs – Duke University School of Medicine, The Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery
    Author: Elizabeth S. S. Miller – Duke University School of Medicine, The Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery
    Author: Gena H. Volas-Redd – Northside Hospital Cancer Institute, Georgia Cancer Specialists
    Poster Presenter: Margaret O. O. Johnson – Duke University School of Medicine, The Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-31 - Targeting Cancer Stem Cells with a CDK2 Inhibitor in Glioblastoma
    Location: Exhibit Hall A/B
    Poster Presenter: Elham Mahmoudian – Uottawa
    Author: Dianbo Qu – Uottawa
    Author: Arezu Jahani-Asl – University of Ottawa
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-32 - Evaluating the therapeutic effects of small molecule inhibitors of CDK4/6 and FAK in preclinical meningioma models
    Location: Exhibit Hall A/B
    Poster Presenter: Nazanin Ijad – Massachusetts General Hospital
    Author: Katie L. Waller – Mayo Clinic
    Author: Naema Nayyar – Massachusetts General Hospital
    Author: Erika Yamazawa – Massachusetts General Hospital
    Author: Elizabeth J. Summers – Massachusetts General Hospital
    Author: Christian Migliarese – Massachusetts General Hospital
    Author: Evanthia Galanis – Mayo Clinic
    Author: Jann N. Sarkaria – Mayo Clinic
    Author: Rachael A. Vaubel – Mayo Clinic
    Author: Hiroaki Wakimoto – Harvard Medical School
    Author: Priscilla K. Brastianos – Massachusetts General Hospital/Harvard Medical School
    Drug discovery, drug resistance
  • Friday, Nov 17th
    7:30 PM – 9:30 PM PT
    DDDR-33 - TNG908, a brain-penetrant MTA-cooperative PRMT5 inhibitor, is efficacious in preclinical MTAP-deleted models including glioblastoma
    Location: Exhibit Hall A/B
    Poster Presenter: Minjie Zhang – Tango Therapeutics
    Author: Alice Tsai – Tango Therapeutics
    Author: Kevin Cottrell – Tango Therapeutics
    Author: Erik Wilker – Tango Therapeutics
    Author: Charles Davis – Tango Therapeutics
    Author: Heather DiBenedetto – Tango Therapeutics
    Author: Ron Weitzman – Tango Therapeutics
    Author: Alan Huang – Tango Therapeutics
    Author: John Maxwell – Tango Therapeutics
    Author: Kimberly Briggs – Tango Therapeutics
    Drug discovery, drug resistance
  • Sunday, Nov 19th
    10:15 AM – 10:25 AM PT
    DDDR-09 - Functional genomics and chemotherapy resistance screening identifies biomarkers and targetable mechanisms of CCNU resistance in gliomas
    Location: Room 109-110
    Oral Abstract Presenter: Cynthia Hajal – Northeastern University / prev. Dana-Farber Cancer Institute
    Author: Simona Dalin – Dana-Farber Cancer Institute
    Author: Greg Raskind – Dana-Farber Cancer Institute
    Author: Margaret Cusick – Dana-Farber Cancer Institute
    Author: Seth Malinowski, Massachusetts – Dana-Farber Cancer Institute
    Author: Jakob Ito – German Cancer Research Center
    Author: Connor Bossi – Dana-Farber Cancer Institute
    Author: Jayne Vogelzang – Dana-Farber Cancer Institute
    Author: Charlotte Bellamy – Paris Brain Institute
    Author: Lisa Salhi – Paris Brain Institute (ICM)
    Author: Franck Bielle – Pitie Salpetriere Hospital
    Author: Gad Getz – Broad Institute of MIT and Harvard
    Author: Pratiti Bandopadhayay – Dana-Farber Cancer Institute
    Author: Mehdi Touat – Pitié Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) Sorbonne Université
    Author: Rameen Beroukhim – Center for Neuro-Oncology, Dana-Farber Cancer Institute
    Author: Keith L. Ligon – Brigham and Women's Hospital
    Drug discovery, drug resistance
  • Sunday, Nov 19th
    10:55 AM – 11:05 AM PT
    DDDR-30 - Identification of drivers of resistance in BRAFV600E pediatric high-grade glioma and novel therapeutic targets
    Location: Room 121-122
    Author: Rebecca Lehmann – Children's Cancer Institute
    Author: Joshua Zhu – Children's Cancer Institute
    Author: Chelsea Mayoh – Children's Cancer Institute
    Author: Maria Tsoli – Children's Cancer Institute
    Author: Benjamin Rayner – Children's Cancer Institute
    Oral Abstract Presenter: David S. Ziegler – Kids Cancer Centre, Sydney Children’s Hospital
    Drug discovery, drug resistance
  • Sunday, Nov 19th
    11:20 AM – 11:25 AM PT
    DDDR-05 - Targeted inhibition of DNA repair and survival signaling in diffuse intrinsic pontine gliomas
    Location: Room 121-122
    Author: Ivana Barravecchia – Center for Molecular Imaging and Department of Radiology, The University of Michigan Medical School
    Author: Monika Sharma – Center for Molecular Imaging and Department of Radiology, The University of Michigan Medical School
    Author: Robert Teis – Center for Molecular Imaging and Department of Radiology, The University of Michigan Medical School
    Author: Jeanette Cruz – Center for Molecular Imaging and Department of Radiology, The University of Michigan Medical School
    Author: Rachel Mumby – Department of Radiology, The University of Michigan Medical School
    Author: Elizabeth Ziemke – Department of Radiology, The University of Michigan Medical School
    Author: Carlos Espinoza – Department of Surgery, The University of Michigan Medical School
    Author: Varunkumar Krishnamoorthy – Center for Molecular Imaging and Department of Radiology, The University of Michigan Medical School
    Author: Brian Magnuson – Department of Biostatistics, School of Public Health, The University of Michigan and Rogel Cancer Center, The University of Michigan Medical School
    Author: Mats Ljungman – Department of Radiation Oncology and Rogel Cancer Center, The University of Michigan Medical School and Center for RNA Biomedicine, The University of Michigan
    Author: Carl J. Koschmann – University of Michigan
    Author: Christopher Whitehead – Department of Radiology, The University of Michigan Medical School
    Author: Judith Sebolt-Leopold – Department of Radiology, Department of Pharmacology, and Rogel Cancer Center, The University of Michigan Medical School
    Oral Abstract Presenter: Stefanie Galban – University of Michigan, Michigan Medicine, Departments of Radiology and Surgery
    Drug discovery, drug resistance
  • Sunday, Nov 19th
    11:25 AM – 11:30 AM PT
    DDDR-07 - Targeting the circadian clock with small molecule compounds results in anti-tumor effects specifically in glioblastoma stem cells
    Location: Room 109-110
    Oral Abstract Presenter: Priscilla Chan – University of Southern California
    Author: Lian Wu – Department of Medicine, University of Pittsburgh Medical Center
    Author: Anahit Hovsepyan – Children's Hospital of Los Angeles
    Author: Seda Mkhitaryan – Children's Hospital of Los Angeles
    Author: Gevorg Karapetyan – Children's Hospital of Los Angeles
    Author: Khalid Shah – Harvard Medical School
    Author: Hiroaki Wakimoto – Harvard Medical School
    Author: Theodore M. Kamenecka – University of Florida
    Author: Laura A. Solt – University of Florida
    Author: Jamie Cope – Synchronicity Pharma
    Author: Rex Moats – Children's Hospital of Los Angeles
    Author: Tsuyoshi Hirota – Nagoya University
    Author: Jeremy N. Rich – University of Pittsburgh, Pennsylvania
    Author: Steve A. Kay – University of Southern California
    Drug discovery, drug resistance