Uppsala University
Uppsala, Uppsala Lan, Sweden
My name is Rebecka, and I am a PhD candidate at Uppsala University in the subject of Neuro-Oncology under the mentorship of Professor Sven Nelander. I received my MSc in Medical Biotechnology Engineering from the Royal Institute of Technology in 2018. In Prof. Nelander’s group we are working with combining data-driven and experimental methods, to investigate nervous system cancer, such as glioblastoma. We want to understand the molecular mechanisms governing growth and invasion and to discover new treatment options. We utilize patient-derived experimental models, molecular biology, and large-scale computation. To explore how cell state plasticity shapes tumor progression, new experimental tools to monitor cell state dynamics in real-time will be important. We have developed a live reporting of GBM cell dynamics that utilize CRISPR/Cas9 and fluorescent proteins for tracking individual glioblastoma patient-derived cells’ physiological gene expression. The method aims to provide real-time reporting of accurate transcriptional phenotypes over extended periods or in relevant in vitro or in vivo contexts.
