University Hospital Heidelberg
Heidelberg, Baden-Wurttemberg, Germany
Matthia Karreman is the leading the subgroup Brain Metastasis in the Winkler Laboratory (DKFZ and University Hospital Heidelberg). Following obtaining her Master of Science in Biology and her PhD at Utrecht University in the Netherlands, she moved to the EMBL Heidelberg for a post-doc in the lab of Dr. Yannick Schwab. Here she developed novel approaches to correlate fluorescence microscopy to 3D-electron microscopy and started a fruitful collaboration with the DKFZ, which spiked her interest in brain metastasis research. Since 2017, she is works on preventative strategies against brain metastasis development. Here, multiphoton intravital imaging through a chronic cranial window in mice is used to visualize the dynamic interactions of brain metastatic cells with their unique microenvironment. As PI in the e:Med Junior Alliance MelBrainSys, she, together with her team, aims to validate candidate genes for melanoma brain metastases development in vivo, hoping to identify novel therapeutic targets.