Lou and Jean Malnati Brain Tumor Institute, Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Chicago, Illinois, United States
Dr. Sachdev is a radiation oncologist who focuses on treatment of benign and malignant brain tumors, brain metastases, spinal cord tumors and vascular lesions (AVMs). He has expertise in the use of GammaKnife/stereotactic radiosurgery (SRS), spine stereotactic radiotherapy (SABR/SBRT) and image-guided highly-conformal radiotherapy.
His research focus is on improving the effectiveness and therapeutic ratio of radiotherapy for CNS malignancies. Modern highly-conformal image-guided radiotherapy can produce high dose gradients in any shape over high resolution (maximally sparing normal tissue) and is a backbone of neuro-oncologic treatment. Many current regimens rely upon the synergy of well-tolerated systemic treatment delivered in conjunction with tumor-directed targeted conformal radiotherapy. If this microenvironment could be further modulated for improved potency and/or immunogenicity, it may not only improve initial tumor response but also prolong the disease-free state through cell-mediated tumor immunity. For therapy recalcitrant brain tumors, such an effect could be significant in improving disease outcomes.
