UMR CNRS 7021 - Team tumor signaling and therapeutic targets
Illkirch-Graffenstaden, France
My name is Marlene Deschuyter, I am 28 years old and I am a post-doctoral researcher. I work in Laboratory of Bioimaging and Pathologies (Team tumor signaling and therapeutic targets), in UMR CNRS 7021, at University of Strasbourg, France.
My research focuses on modelling pediatric brain tumors and ostesarcomas based on organoid technology. Using fresh samples or PDX (Patient Derived Xenograft), we try to create organoids derived tumor (tumoroids) for each tumor types. Using different conditions (hypoxia, media), we try to reproduce, in vitro, the tumoral environment. Once these models have been generated, we will try to make them resistant to treatments used routinely, in order to identify mechanisms involved in these phenomena, as these tumors are characterized by significant resistance and relapse events. We used several technologies to validate our models, based on genetic alterations, epigenetic (methylation) and morphological comparisons.
Before my post-doctoral position, I did my PhD in France (Limoges), and worked on post-translational modifications (O-fucosylation and sialylation) involved in colorectal tumorigenesis and progression. I have a great expertise in cell culture, in cell biology and biochemistry.
