Brigham and Women's Hospital and Harvard Medical School
Boston, Massachusetts, United States
Anna Krichevsky is an Associate Professor of Neurology/Neurobiology at Brigham and Women’s Hospital and Harvard Medical School in Boston, USA. She earned her Ph.D. from the Hebrew University of Jerusalem, Israel, and completed her postdoctoral training at Harvard Medical School. As a postdoctoral fellow, Dr. Krichevsky isolated neuronal RNA granules and pioneering research that contributed to our understanding of microRNA functions and RNA interference mechanisms in brain physiology and pathology. She performed the first successful RNA interference in mammalian neurons, contributed to the identification of miRNAs in the mammalian brain, developed the first high-throughput arrays for miRNA expression profiling, and discovered oncogenic miRNAs, miR-21 and miR-10b, in glioblastoma- both are promising targets for high-grade gliomas and other oncologic diseases. Krichevsky laboratory identified and studied key miRNAs and other non-coding RNAs implicated in brain tumors and neurodegenerative disorders such as Alzheimer's disease and multiple sclerosis. The lab also led the way in identifying miRNA biomarkers for diagnostics and monitoring of primary and metastatic brain tumors. Dr. Krichevsky’s ongoing research is concentrated on two main areas: 1) revealing the targetable hubs associated with RNA pathologies, and 2) developing therapeutic strategies for targeting regulatory RNA species for neuro-oncologic and neurodegenerative diseases. Additionally, she also serves on the Executive Committee of the Harvard Medical School Initiative for RNA Medicine, which aims to translate RNA research into clinical practice.
