University of California, San Francisco
San Francisco, United States
Patrick Schupp, UCSF Translational Brain Tumor Research Fellow, Graduate Student, UCSF Biomedical Sciences
I study the the heterogeneity of gliomas and surrounding tissues using mutli-omic methodologies and start-of-the-art deconvolution analyses. Specifically, I use serial sections of glioma samples to derive biologically important vectors of covariation and infer changes in cellular abundance and cell state through a tumor. I then use orthogonal methodologies to validate this approach, as well as to deduce causal relationships between, for example, certain mutations and changes in cell state. Similarly I use publicly available data to perform similar analysis using thousands of glioma and normal samples. In either case, I am able to correct for tumor heterogeneity at the level of a single tumor or the level of thousands of tumors to infer causal relationships. In this way I am able to achieve cellular resolution while still sampling billions of cells in a relatively unbiased fashion.
