University of California, San Francisco
San Francisco, United States
Michael C. Oldham, PhD is an Associate Professor in the Brain Tumor Center and Department of Neurological Surgery at the University of California, San Francisco. His lab develops and applies computational and experimental strategies for deconstructing the cellular and molecular heterogeneity of normal human brain and brain tumor specimens, with an emphasis on adult malignant gliomas. Computationally, these strategies include meta-analysis of feature covariation (e.g., gene coexpression) over thousands of samples representing billions of cells. Experimentally, these strategies include standardized sampling and automated data production to generate benchmark datasets for developing and testing statistical models of biological systems. The Oldham Lab has a strong interest in using these strategies to develop novel therapies for gliomas that target the tumor microenvironment, in particular the vasculature. Dr. Oldham also has a keen interest in metascientific topics, including the reproducibility crisis and the future of scholarly communication.
