Department of Neurosurgery, Department of Cell and Developmental Biology, University of Michigan
Ann Arbor, Michigan, United States
Dr. Haase obtained his PhD from the Faculty of Sciences of the University of La Plata (Argentina), where he studied the molecular design of improved viral biopesticides to treat crop pests. He joined the Castro-Lowenstein lab in 2017, to work on the molecular biology of pediatric high-grade gliomas. Santiago’s work focuses on an understudied molecular subtype of pediatric high-grade gliomas, which harbors mutations on a histone gene (G34R/V mutations). The findings of this project led us to the identification of molecular vulnerabilities in these tumors, which led us to discover a link between DNA damage defects, genetic instability, and the immune response, and the work proved the potential of DNA damage response targeted therapies to treat G34-mutant gliomas.
