Mayo Clinic Rochester MN
Rochester, Minnesota, United States
Robert Brian Jenkins, MD, PhD. Ting Tsung and WeiFong Chao Professor of Individulized Medicine Research, Mayo Clinic
Focus on the biology, genetics, diagnosis and treatment of glioma
- Discovery of (and the translocation mechanism) of 1p/19q codeletion in oligodendroglioma. Now an essential element is the diagnosis of these tumors.
- Discovery (as co-PI) of the clinical responsiveness of co-deleted and IDH-mutant oligodendroglioma to PCV and RT. Became the standard for practice for the treatment of these tumors (2005 JCO and other publications)
- Discovery that low-grade gliomas with TERT-promoter mutation behave a glioblastoma. Now a critical part of standard diagnostic test of gliomas (with Drs. Lachance and Eckel-Passow (2015 NEJM and other publications)
- PI of the first of two glioma GWAS (2009 Nature Genetics -paired publications)
- Mapping of the 8q24 risk allele associated with the development of IDH-mutant gliomas, with the discovery a variant with a ~6-fold risk of developing these tumors (2012 Nature Genetics).
- Ascertainment of the mechanism of action of the 8q24 risk allele (2020 Science; with commentary in Cancer Discovery and NEJM – Clinical implications of Basic Research. One of EACR and the NCI Epidemiology Branch cancer discoveries of the year).
- Development of multiple clinical brain tumor tests. Most recently: clinical NGS and array tests.
