Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, York Street, Dublin 2
Dublin, Dublin, Ireland
I completed my Bachelor's degree in Biological and Medical Sciences at the University of Liverpool, graduating in 2018. Following completion of my Undergraduate degree, I was involved in the RCSI StAR summer internship scheme where I worked on a project to investigate the improvement of drug delivery in Glioblastoma using nanotherapeutics.
Following on from the StAR internship, I was accepted onto the GLIOTRAIN PhD programme funded by the European Union’s Horizon 2020 research and innovation programme under Marie Sklodowska-Curie grant agreement No 766069. My research project is focused on ‘Identifying new tumour microenvironment (TME) contexts of vulnerability in glioblastoma.’ During this project, we studied multi-omic profiling datasets from >800 GBM patient samples. This analysis revealed novel TME classifiers which may support future precision immunotherapy approaches in intracranial malignancies.
During my PhD project, I have been fortunate to spend time on secondment at INSERM Paris, where we performed multiplex immunohistochemistry to modify and validate the MCP-counter method for application in GBM. Moreover, during a virtual secondment with the Jackson Laboratory (JAX), we have looked at the effect of extrachromosomal DNA (ecDNA) on the GBM TME.
I completed my PhD in Feb 2023 and started a post-doctoral research position in the PCMG. This project, titled ‘Interrogation of novel Glioblastoma Subtypes towards an improved Precision Medicine Approach for Brain Tumour Patients’, is building on from my PhD findings.
